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Characteristics of Individualised Infection Medicine
Characteristics of Individualised Infection Medicine The page is under construction.
Facets and added value of Individualised Medicine
Facets and added value of Individualised Medicine The page is under construction.
Clinical Bioinformatics
Personalized medicine offers a significant opportunity to enhance public health by accounting for individual variability in genes, environment, and lifestyle. The "Clinical Bioinformatics" research group follows this direction, aiming to unravel the intricate molecular mechanisms underlying infection and aging. Through this pursuit, we strive to develop precise, individualized treatment strategies. Our research aims to develop and apply "bioinformatics approaches" to pinpoint the genetic and epigenetic factors influencing infection-induced immune responses by integrating multi-omics data from patients and constructing computational models that predict an individual’s risk of infectious diseases. We interact with experimental collaborators and clinical experts to verify our findings and promote their translation into medical treatments or diagnostic procedures. Our ultimate goal is to contribute to the main research focus of CiiM/MHH: the tailored and improved prevention, diagnosis, and treatment of infectious diseases and cancer for individual patients or patient groups. Within this framework, the team led by Prof. Dr. Cheng-Jian Xu is primarily dedicated to the domains of diagnosis, risk assessment, early detection, and patient stratification.
Computational Biology for Individualised Medicine
Infections are among the biggest threats to health and the most significant causes of death worldwide. Our aim is to reveal the host genetic risk factors and their downstream molecular pathways, which are crucial to make progress in understanding and treating infectious diseases in an individualised manner as well as to improve the identification of patients at risk. The department of the HZI is part of the developing CiiM and currently housed at the TWINCORE in Hannover. Our group currently has 6 PhD students and 5 postdocs. Students and postdocs – We are always looking for bright and enthusiastic students and postdocs (funded by e.g. the ERC starting grant). For more about our projects, please contact us by email.
Individualised Medicine for Viral Infections
Opportunistic infections remain a serious threat to immunocompromised individuals, such as transplant recipients. We study opportunistic herpes viruses, such as the cytomegalovirus (CMV) by developing unique technologies for real-time measurement of virus growth, allowing us rapid identification of antiviral activity of primary samples and virtually any immune cell subset. This allows us to identify at-risk populations and develop targeted antiviral therapies for treatment and prevention of opportunistic viral infections. In the course of the COVID pandemic, our expertise in virus genetics was used to clone pseudoviruses expressing variants of the SARS-CoV-2 spike protein for the assessment of the neutralization capacity of sera or monoclonal antibodies, and this technology is pursued in the identification of correlates of immune protection in vaccinated or convalescent populations. We team with local and international teams of physicians and epidemiologists, providing technical support and scientific advice on complex laboratory serological diagnostics. In March 2019, Prof Dr. Dr. Luka Cicin-Sain was jointly appointed by the MHH (Hannover Medical School) and HZI (Helmholtz Centre for Infection Research) as CIIM Professor for "Individualised Medicine of Viral Infections", and as of 2021 he leads the CiiM-associated Department of “Viral Immunology” (VIRI) at the Helmholtz Centre for Infection Research in Braunschweig.
Jobs at CiiM
Jobs at CiiM Applications Join the team CiiM is growing and the CiiM groups are always happy to receive applications from motivated and qualified candidates. Open job advertisements can be found on the group pages. In addition, speculative applications are…
CIIM
Centre for Individualised Infection Medicine The CiiM, based in Hannover, is a joint research institute of the Helmholtz Centre for Infection Research and the Hannover Medical School. More about the CiiM What is individualised medicine? For some years now,…
Data protection
Data protection Data protection Thank you for your interest in our website. The Helmholtz Centre for Infection Research (HZI) takes the protection of personal data very seriously. It is possible to use our website without providing any personal data. This…
Jobs
Jobs © AdobeStock_294726409 Initiativbewerbungen Become part of the team We are always interested in receiving applications from motivated candidates. More Contact Dr Jennifer Debarry Head of Office - CiiM CiiM +49 511 22002 7226 E-Mail
What is Individualised Medicine?
What is Individualised Medicine? Topics What is Individualised Medicine? In medicine, the development and application of therapies with maximum efficacy and minimum side effects remains a fundamental challenge. In fact, approved therapies and medicines…